Population pharmacokinetics of valproate in Chinese children with epilepsy
نویسندگان
چکیده
منابع مشابه
Population pharmacokinetic model of valproate and prediction of valproate serum concentrations in children with epilepsy.
AIM Using sparse data of valproate (VPA) serum concentrations to build a population pharmacokinetic (PPK) model of VPA in Chinese children with epilepsy and to predict serum concentrations for new patients using a Bayesian approach. METHODS Two hundred epileptic children, whose VPA serum concentrations were collected, were divided randomly into two groups (A and B, n=100 each). The PPK parame...
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Background Epilepsy is one of the most common neurological diseases. Over the last decades the hypothesis of cardiovascular effects from sudden seizure has been raised, and cardiac rhythm and ECG changes in these patients have been highlighted. The study aimed to evalua...
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چکیده ندارد.
15 صفحه اولValproate in Treatment of Epilepsy
Sodium valproate has a simple chemical structure unlike other anticonvulsants. It has been given to 63 patients with various types of epilepsy whose attacks were frequent and of whom 40 had failed to respond to other anticonvulsants. Fits stopped completely in 27 patients (43%) and 14 (22%) showed a reduction ofattacks by more than 50%. The best results were in patients with absences (typical a...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2007
ISSN: 1671-4083,1745-7254
DOI: 10.1111/j.1745-7254.2007.00704.x